inclusion body neurofibrillary tangle GO:0097418 2012-11-06T16:49:35Z pr NIF_Subcellular:nlx_subcell_20090201 Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. NIF_Subcellular:nlx_subcell_20090202 star-shaped neurofibrillary tangle flame-shaped neurofibrillary tangle Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267). cellular_component NIF_Subcellular:sao2409833926