protein-DNA complex transcription preinitiation complex preinitiation complex PIC transcriptional pre-initiation complex 2014-01-22T09:33:44Z DNA-templated transcriptional preinitiation complex A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. pr GO:0097550 transcriptional preinitiation complex cellular_component