ubiquitin-like protein peptidase activity deubiquitinase activity https://github.com/geneontology/go-ontology/issues/17398 There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases. 2016-02-08T09:39:38Z molecular_function An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. Reactome:R-HSA-9929353 ubiquitinyl hydrolase activity mec GO:1904265 GO:0101005 Reactome:R-HSA-9674127