(2E)-enoyl-CoA hydratase activity very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity https://github.com/geneontology/go-ontology/issues/24738 https://github.com/geneontology/go-ontology/issues/25805 https://github.com/geneontology/go-ontology/issues/30193 EC:4.2.1.134 GO:0102158 MetaCyc:RXN-11750 molecular_function RHEA:39271 RHEA:79187 RHEA:45812 RHEA:39211 RHEA:39199 very-long-chain 3-hydroxyacyl-CoA dehydratase activity Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA. This reaction is the third (dehydration) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. RHEA:39235 RHEA:39223 RHEA:83119