2-oxoglutarate-dependent dioxygenase activity L-isoleucine 4-hydroxylase activity https://github.com/geneontology/go-ontology/issues/31862 https://github.com/geneontology/go-ontology/issues/31969 RHEA:41448 molecular_function Catalysis of the reaction: L-isoleucine + 2-oxoglutarate + O2 = (4S)-4-hydroxy-L-isoleucine + succinate + CO2. EC:1.14.11.45 MetaCyc:RXN-13637 4-hydroxy-L-isoleucine dehydrogenase activity GO:0102394