oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor very-long-chain enoyl-CoA reductase activity https://github.com/geneontology/go-ontology/issues/25304 https://github.com/geneontology/go-ontology/issues/25805 https://github.com/geneontology/go-ontology/issues/30193 Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + NADP+ = a very-long-chain (2E)-enoyl-CoA + H+ + NADPH. This reaction is the fourth (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. RHEA:14473 molecular_function RHEA:85835 GO:0102758 MetaCyc:RXN-7711 EC:1.3.1.93