protein-containing complex amyloid-beta complex homooligomer of amyloid beta protein 2017-03-15T19:19:29Z hjd homodimer of amyloid beta protein amyloid-beta protein 40/42 complex amyloid beta trimer amyloid beta heterotrimer amyloid beta oligomer Abeta complex GO:0106003 amyloid beta homodimer betaA complex heterodimer of amyloid beta protein amyloid beta homooligomer amyloid-beta protein 40 complex beta amyloid complex heterooligomer of amyloid beta protein Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease. beta-amyloid complex Abeta-derived diffusible ligand complex ADDL complex amyloid beta heterooligomer amyloid beta dimer cellular_component homotrimer of amyloid beta protein amyloid beta heterodimer An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay). heterotrimer of amyloid beta protein amyloid beta complex amyloid beta homotrimer amyloid-beta protein 42 complex