PAR polarity complex https://github.com/geneontology/go-ontology/issues/15715 krc GO:0120157 A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. apical polarity complex PAR3-PAR6-atypical PKC Cdc42p GEF-PAK complex "This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4. BEM1-CDC24-CLA4 complex PAR6-PAR3-aPKC complex PAR3/PAR6/aPKC cellular_component 2018-05-11T15:41:30Z serine/threonine protein kinase complex