protein quality control for misfolded or incompletely synthesized proteins cytoplasm protein quality control https://github.com/geneontology/go-ontology/issues/19172 GO:0140455 biological_process pg 2020-04-20T15:46:20Z The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding.