cellular response to stress integrated stress response signaling https://github.com/geneontology/go-ontology/issues/19153 https://github.com/geneontology/go-ontology/issues/27550 biological_process GO:0140467 2020-05-26T08:04:10Z pg The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. Wikipedia:Integrated_stress_response ISR intracellular signaling cassette