integrated stress response signaling HRI-mediated signaling https://github.com/geneontology/go-ontology/issues/19153 2020-05-26T08:46:15Z EIF2AK1-mediated signaling pg A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. biological_process GO:0140468