integrated stress response signaling GCN2-mediated signaling https://github.com/geneontology/go-ontology/issues/15399 https://github.com/geneontology/go-ontology/issues/19153 EIF2AK4-mediated signaling pg biological_process GO:0140469 2020-05-26T08:47:25Z regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0060733 A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation.