proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway https://github.com/geneontology/go-ontology/issues/21184 The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. DesCEND GO:0140627 2021-03-24T07:30:47Z biological_process pg