histone H3R8 arginine deiminase activity https://github.com/geneontology/go-ontology/issues/23152 https://github.com/geneontology/go-ontology/issues/28520 https://github.com/geneontology/go-ontology/issues/30578 H3-R8 citrullination histone H3-R8 arginine deiminase activity histone-arginine deiminase activity (H3-R8 specific) Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism. The substrate for histone deiminase may be methyl-arginine, rather than arginine (see PMID:35197210 and PMID:16567635). pg Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8. molecular_function GO:0140796 2022-04-06T13:11:13Z histone H3 arginine deiminase activity