RNA polymerase II CTD heptapeptide repeat kinase activity RNA polymerase II CTD heptapeptide repeat S2 kinase activity https://github.com/geneontology/go-ontology/issues/23389 https://github.com/geneontology/go-ontology/issues/28520 RNA polymerase II C-terminal domain S2 kinase activity molecular_function 2022-05-24T13:52:21Z pg Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 2). GO:0140834