intracellular signaling cassette cAMP/PKA signal transduction https://github.com/geneontology/go-ontology/issues/26899 An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell. GO:0141156 cAMP/PKA signaling cassette pg protein kinase A signaling 2024-02-01T08:21:03Z PKA signaling cAMP signaling Reactome:R-HSA-163358 biological_process