chromosomal 5-methylcytosine DNA demethylation pathway chromosomal 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway https://github.com/geneontology/go-ontology/issues/27078 epigenetic 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway pg 2024-02-16T14:20:55Z Note that this term describes one of the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child. An epigenetic cytosine DNA demethylation pathway that involves a DNA glycosylase that directly excises 5-methylcytosine (5-meC) to initiate its replacement with unmethylated cytosine through base excision repair. This pathway is known to occur in plants. In addition to CG sites, plants also methylate cytosines within CHH and CNG sequences. biological_process GO:0141169