intracellular signaling cassette phospholipase C/protein kinase C signal transduction https://github.com/geneontology/go-ontology/issues/28410 2024-07-08T14:39:30Z GO:0141212 An intracellular signaling cassette that starts with activation of phospholipase C (PLC) activity and ends with the activation of protein kinase C (PKC). PLC produces inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors. This cassette is often part of the phospholipase C-activating G protein-coupled receptor signaling pathway. biological_process PLC/PKC signaling PLC/PKC/PKD signaling pg