modification-dependent protein binding ADP-D-ribose modification-dependent protein binding rl GO:0160002 2021-07-12T23:31:53Z molecular_function Binding to a protein upon ADP-ribosylation of the target protein. This term should only be used when the binding is shown to require a ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term.