has part protein activation cascade signaling receptor ligand precursor processing Toll receptor ligand protein activation cascade https://github.com/geneontology/go-ontology/issues/23378 biological_process GO:0160032 This term specifically mentions the Toll receptor and its ligand spatzle because this is the only known example of such an activation cascade for a ligand. rynl 2022-06-07T23:48:31Z A protein activation cascade that generates the active Toll receptor ligand and consists of the cascade of enzymatic reactions initiated by extracellular recognition factors, leading to the cleavage of the inactive form of spatzle family of ligands.