alpha-ketoacid dehydrogenase complex branched-chain alpha-ketoacid dehydrogenase complex https://github.com/geneontology/go-ontology/issues/26881 https://github.com/geneontology/go-ontology/issues/29951 cellular_component BKDH complex BCKD complex A multi-enzyme complex that catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: branched-chain alpha-ketoacid dehydrogenase (E1, a heterotetramer of two alpha and two beta subunits), dihydrolipoyl transacylase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. Wikipedia:Branched-chain_alpha-keto_acid_dehydrogenase_complex rynl The catalytic activities of the individual components of this complex are represented by the molecular function terms '3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity ; GO:0003863' (E1), 'dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity ; GO:0043754' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). 2024-01-26T18:18:12Z GO:0160157 transferase complex