nonsense-mediated decay complex https://github.com/geneontology/go-ontology/issues/15365 ew 2023-02-02T16:55:18Z IntAct:EBI-16420380 Upf complex GO:0170010 A highly conserved protein complex that recognises and elicits the rapid degradation of mRNAs in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. cellular_component catalytic complex