histone decrotonylase activity, NAD-dependent histone H3K18 decrotonylase activity https://github.com/geneontology/go-ontology/issues/24466 https://github.com/geneontology/go-ontology/issues/28520 2023-02-09T20:55:09Z molecular_function GO:0170012 Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism. Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone H3 position 18] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone H3] + nicotinamide. ew