RNA ligase activity RNA ligase (GTP) activity https://github.com/geneontology/go-ontology/issues/27418 MetaCyc:RXN-17905 2024-03-26T23:34:04Z GO:0170057 EC:6.5.1.8 molecular_function ew Catalysis of the joining of an RNA with 3'-phosphate or 2',3'-cyclic-phosphate ends to an RNA with 5'-hydroxy ends according to either (i) a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP; or (ii) a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H+. RHEA:68080 MetaCyc:RXN0-6566 RHEA:68076 3'-phosphate/5'-hydroxy nucleic acid ligase activity