part of catalytic activity nonribosomal peptide biosynthetic process non-ribosomal peptide synthetase activity https://github.com/geneontology/go-ontology/issues/7340 PCP pr 2015-03-26T10:41:52Z Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization. peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process. peptidyl carrier protein molecular_function peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis GO:1904091 peptidyl carrier protein activity