intrinsic apoptotic signaling pathway in response to osmotic stress intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator 2013-06-19T13:55:06Z GO:1990127 The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered. biological_process pr