part of endoplasmic reticulum membrane membrane protein complex endoplasmic reticulum protein-containing complex serine/threonine protein kinase complex endoribonuclease complex Ire1 complex https://github.com/geneontology/go-ontology/issues/26879 bhm ERN1 complex An example of this is Ire1 in S. cerevisiae (P32361) in PMID:18191223 (inferred from direct assay). GO:1990332 Ire1 complex homodimer A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript. Ire1 complex dimer 2014-03-17T10:46:58Z ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1 IRE1 dimer Ire1 complex homooligomer cellular_component