part of spindle pole body GTPase activator complex SIN/MEN two-component GAP complex https://github.com/geneontology/go-ontology/issues/31636 Bfa1-Bub2 complex 2014-03-17T14:34:21Z A protein complex that acts as a two-component GTPase-activating protein for the Tem1/Spg1 GTPase, thus regulating a signal transduction cascade (the mitotic exit network, MEN, in budding yeast; the septation initiation network, SIN, in fission yeast), which is required for mitotic exit and cytokinesis. The complex keeps the GTPase inactive until the spindle is properly oriented, thus inhibiting MEN/SIN activation. bhm GO:1990334 cellular_component Byr4-Cdc16 GAP complex