RNA polymerase II transcription regulator complex Nkx-2.5 complex ame Nkx-2.5 homodimer complex NKX2.5 complex cellular_component An example of this is Nkx-2.5 in human (UniProt symbol P52952) in PMID:22849347 (inferred from direct assay). A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes. NKX.2-5 homodimer complex NKX2E homodimer complex GO:1990664 2015-02-27T12:22:06Z