buserelin http://purl.bioontology.org/ontology/MESH/D002064 http://purl.bioontology.org/ontology/SNOMEDCT/395744006 http://purl.obolibrary.org/obo/CHEBI_135907 http://purl.obolibrary.org/obo/NCIT_C320 https://en.wikipedia.org/wiki/Buserelin https://www.wikidata.org/wiki/Q414745 A potent synthetic analog of gonadotropin-releasing hormone with D-serine substitution at residue 6, glycine10 deletion, and other modifications. A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. L02AE01 oligopeptide gonadotropin-releasing hormone analog