estradiol acetate http://purl.bioontology.org/ontology/SNOMEDCT/414140005 http://purl.obolibrary.org/obo/CHEBI_135981 http://purl.obolibrary.org/obo/NCIT_C47990 https://en.wikipedia.org/wiki/Estradiol_acetate https://www.wikidata.org/wiki/Q5401757 EA The acetate salt form of estradiol, the most potent, naturally produced estrogen. Estradiol acetate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics. estradiol estradiol ester therapeutic estradiol