3-oxo-5α-steroid 17β-hydroxy-5α-androstan-3-one http://purl.bioontology.org/ontology/MESH/D013196 http://purl.bioontology.org/ontology/SNOMEDCT/103042004 http://purl.obolibrary.org/obo/CHEBI_16330 http://purl.obolibrary.org/obo/NCIT_C29619 https://en.wikipedia.org/wiki/Androstanolone https://en.wikipedia.org/wiki/Dihydrotestosterone https://www.wikidata.org/wiki/Q31686490 https://www.wikidata.org/wiki/Q411054 A14AA01 17beta-hydroxy-5alpha-androstan-3-one A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5. A potent androgenic metabolite of testosterone. It is produced by the action of the enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase. The most potent androgen, required for sex development. Dihydrotestosterone is synthesized from testosterone in the prostate gland, testes, hair follicles and adrenal glands by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone, which binds to and activates specific nuclear androgen receptors. After translocation into the nucleus, the activated hormone-receptor complex binds to the androgen response elements on the DNA and activates gene expressions that are required for sex development. Dihydrotestosterone is responsible for the formation of male primary sex characteristics and most male secondary sex characteristics during puberty, such as muscular growth, facial and body hair growth, and deepening of the voice. androstanolone dihydrotestosterone stanolone 17β-hydroxy steroid 17β-hydroxyandrostan-3-one The Complete Dictionary of Sexology