progesterone http://purl.bioontology.org/ontology/MEDDRA/10063291 http://purl.bioontology.org/ontology/MESH/D011374 http://purl.bioontology.org/ontology/RXNORM/8727 http://purl.bioontology.org/ontology/SNOMEDCT/16683002 http://purl.obolibrary.org/obo/CHEBI_17026 http://purl.obolibrary.org/obo/NCIT_C2297 https://en.wikipedia.org/wiki/Category:Progesterone https://en.wikipedia.org/wiki/Progesterone https://en.wikipedia.org/wiki/Progesterone_(medication) G03DA04 Produced in the corpus luteum and by the placenta, as an antagonist of estrogens. Promotes proliferation of uterine mucosa and the implantation of the blastocyst, prevents further follicular development. The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands and the brain. It is required in embryo implantation; pregnancy maintenance, and the development of mammary tissue for milk production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. 20-oxo steroid 3-oxo-Δ4 steroid C21-steroid hormone