estradiol http://id.loc.gov/authorities/subjects/sh85045006 http://purl.bioontology.org/ontology/MEDDRA/10015499 http://purl.bioontology.org/ontology/MESH/D004958 http://purl.bioontology.org/ontology/SNOMEDCT/126172005 http://purl.obolibrary.org/obo/CHEBI_23965 http://purl.obolibrary.org/obo/NCIT_C2295 https://en.wikipedia.org/wiki/Category:Estradiol https://en.wikipedia.org/wiki/Estradiol https://en.wikipedia.org/wiki/Estradiol_(medication) G03CA03 QP572.E8 The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol. 17-hydroxy steroid The Complete Dictionary of Sexology