methyl ester cocaine http://homosaurus.org/v2/cocaine http://id.loc.gov/authorities/subjects/sh85027558 http://purl.bioontology.org/ontology/MESH/D003042 http://purl.bioontology.org/ontology/RXNORM/2653 http://purl.bioontology.org/ontology/SNOMEDCT/387085005 http://purl.obolibrary.org/obo/CHEBI_27958 http://purl.obolibrary.org/obo/NCIT_C80153 https://en.wikipedia.org/wiki/Category:Cocaine https://en.wikipedia.org/wiki/Cocaine https://en.wikipedia.org/wiki/Cocaine_(data_page) https://homosaurus.org/terms/cocaine https://homosaurus.org/v3/homoit0000291 https://www.wikidata.org/wiki/Q41576 A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. RD86.C6 A tropane alkaloid with central nervous systems (CNS) stimulating and local anesthetic activity. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may result in increased postsynaptic receptor activation. The mechanism of action through which cocaine exerts its local anesthetic effects is by binding to and blocking the voltage-gated sodium channels in the neuronal cell membrane. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation. An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. coke benzoate ester tropane alkaloid tertiary amino compound natural aphrodisiac