chlormadinone acetate http://purl.bioontology.org/ontology/MESH/D002715 http://purl.bioontology.org/ontology/SNOMEDCT/734647009 http://purl.obolibrary.org/obo/CHEBI_31394 http://purl.obolibrary.org/obo/NCIT_C365 https://en.wikipedia.org/wiki/Chlormadinone_acetate https://www.wikidata.org/wiki/Q5102980 An orally active synthetic progestational hormone used often in combinations as an oral contraceptive. CMA The actetate salt form of chlormadinone, a synthetic progestin with antiandrogenic and antigonadotropic effects. Chlormadinone acetate (CMA) is a potent progesterone receptor (PR) agonist, a partial androgen receptor (AR) antagonist and a weak glucocorticoid receptor (GR) antagonist. Chlormadinone binds to PRs, which induces the expression of progesterone-responsive genes. In addition, chlormadinone blocks ARs in target organs and reduces the activity of skin 5 alpha-reductase; thus inhibiting androgen production and signaling. Through the negative feedback action on the hypothalamus-pituitary system, chlormadinone also suppresses gonadotropin secretion, which prevents ovarian and adrenal androgen production. Therefore, this agent decreases endometrial thickness, increases the viscosity of cervical mucus, inhibits ovulation and suppresses follicular growth and maturation. corticosteroid hormone