estradiol estradiol 17β-cyclopentylpropionate http://purl.bioontology.org/ontology/SNOMEDCT/109028003 http://purl.obolibrary.org/obo/CHEBI_34745 https://en.wikipedia.org/wiki/Estradiol_cypionate https://www.wikidata.org/wiki/Q5401760 The cypionate salt form of estradiol, the most potent, naturally produced estrogen. Estradiol cypionate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics. estradiol 17beta-cyclopentylpropionate estradiol cypionate estradiol ester therapeutic estradiol