monocarboxylic acid amide flutamide http://purl.bioontology.org/ontology/MESH/D005485 http://purl.bioontology.org/ontology/RXNORM/4508 http://purl.bioontology.org/ontology/SNOMEDCT/387587007 http://purl.obolibrary.org/obo/CHEBI_5132 http://purl.obolibrary.org/obo/NCIT_C509 https://en.wikipedia.org/wiki/Flutamide https://www.wikidata.org/wiki/Q418669 L02BB01 A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (trifluoromethyl)benzene