steroid lactone oxaspiro compound 3-oxo-Δ4 steroid thioester spironolactone http://id.loc.gov/authorities/subjects/sh85126790 http://purl.bioontology.org/ontology/MESH/D013148 http://purl.bioontology.org/ontology/RXNORM/9997 http://purl.bioontology.org/ontology/SNOMEDCT/387078006 http://purl.obolibrary.org/obo/CHEBI_9241 http://purl.obolibrary.org/obo/NCIT_C840 https://en.wikipedia.org/wiki/Spironolactone https://www.wikidata.org/wiki/Q422188 A medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease. It is also used in the treatment of high blood pressure, low blood potassium that does not improve with supplementation, early puberty in boys, acne and excessive hair growth in women, and as a part of feminizing hormone therapy in transgender women. A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7. A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Aldactone The Complete Dictionary of Sexology Cyproterone acetate or spironolactone in lowering testosterone concentrations for transgender individuals receiving estradiol therapy