North America Central America http://purl.obolibrary.org/obo/NCIT_C90602 https://en.wikipedia.org/wiki/Central_America https://www.wikidata.org/wiki/Q27611 A region of southern North America extending from the southern border of Mexico to the northern border of Colombia. It separates the Caribbean Sea from the Pacific Ocean and is linked to South America by the Isthmus of Panama. Central American The isthmus joining North America and South America, extending from the southern border of Mexico to the northern border of Colombia.