pure gonadal dysgenesis 46,XX gonadal dysgenesis http://purl.bioontology.org/ontology/MESH/D023961 http://purl.obolibrary.org/obo/DOID_14450 https://en.wikipedia.org/wiki/XX_gonadal_dysgenesis 46 XX gonadal dysgenesis 46,XX pure gonadal dysgenesis Gonadal dysgenesis with a karyotype of 46,XX. Streak ovaries are present with non-functional tissues unable to produce the required sex steroid estrogen. Low levels of oestrogen effect the HPG axis with no feedback to the anterior pituitary to inhibit the secretion of FSH and LH. FSH and LH are secreted at abnormal elevated levels. Improper levels of these hormones will cause a failure to initiate puberty, undergo menarche, and develop secondary sex characteristics. If sufficient functional ovarian tissue is present, limited menstrual cycles can occur. XX gonadal dysgenesis gonadal dysgenesis, XX type