estradiol estradiol ester polyestradiol phosphate http://purl.bioontology.org/ontology/MESH/C008958 http://purl.bioontology.org/ontology/SNOMEDCT/126084009 http://purl.obolibrary.org/obo/NCIT_C1199 https://en.wikipedia.org/wiki/Polyestradiol_phosphate https://www.wikidata.org/wiki/Q7226308 A synthetic long-acting polymer derivative of the sex hormone estradiol. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Administration of polyestradiol phosphate leads to the marked decrease of testosterone levels and may exhibit a bone mass-preserving effect in patients with prostatic cancer. An estrogen medication which is used primarily in the treatment of prostate cancer in men. It is also used in women to treat breast cancer, as a component of hormone therapy to treat low estrogen levels and menopausal symptoms, and as a component of feminizing hormone therapy for transgender women. PEP therapeutic estradiol