mitochondrial replacement therapy http://purl.bioontology.org/ontology/MESH/D000069321 https://en.wikipedia.org/wiki/Mitochondrial_replacement_therapy https://www.wikidata.org/wiki/Q7797271 In vitro fertilization technique that uses mitochondrial DNA from a healthy donor in order to prevent the transmission of mitochondrial disease. MRT The replacement of mitochondria in one or more cells to prevent or ameliorate disease. MRT originated as a special form of in vitro fertilisation in which some or all of the future baby's mitochondrial DNA comes from a third party. This technique is used in cases when mothers carry genes for mitochondrial diseases. The therapy is approved for use in the United Kingdom. A second application is to use autologous mitochondria to replace mitochondria in damaged tissue to restore the tissue to a functional state. This has been used in clinical research in the United States to treat cardiac-compromised newborns. mitochondrial donation mitochondrial replacement therapies replacement therapy