addictive behavior disorder substance addiction http://purl.bioontology.org/ontology/MEDDRA/10001125 http://purl.obolibrary.org/obo/NCIT_C3479 Physical and/or psychological dependence to any substance. Substance addiction is compulsive use of a substance that is independent of withdrawal; substance dependence is a disorder in which cessation of substance use can cause withdrawal which may lead to further substance use. addiction drug addiction substance-related addiction substance dependence substance-use disorder