substance addiction substance dependence http://purl.bioontology.org/ontology/MEDDRA/10012335 http://purl.bioontology.org/ontology/MEDDRA/10076595 http://purl.obolibrary.org/obo/DOID_9973 http://purl.obolibrary.org/obo/NCIT_C35458 https://en.wikipedia.org/wiki/Category:Substance_dependence https://en.wikipedia.org/wiki/Substance_dependence https://www.wikidata.org/wiki/Q3378593 Substance addiction is compulsive use of a substance that is independent of withdrawal; substance dependence is a disorder in which cessation of substance use can cause withdrawal which may lead to further substance use. The psychological or physiological need to take a substance in order to experience its effects or to avoid the effects of its absence. dependence drug dependence substance-use disorder