substance use polysubstance use https://en.wikipedia.org/wiki/Poly_drug_use https://www.wikidata.org/wiki/Q1639827 The use of combined psychoactive substances to achieve a particular effect. In many cases one drug is used as a base or primary drug, with additional drugs to leaven or compensate for the side effects of the primary drug and make the experience more enjoyable with drug synergy effects, or to supplement for primary drug when supply is low. poly drug use polysubstance abuse