SOX transcription factor human sex determining region Y, mRNA sex-determining region Y protein http://identifiers.org/ensembl/ENSP00000372547 http://purl.bioontology.org/ontology/MESH/D051876 https://en.wikipedia.org/wiki/Testis-determining_factor https://www.ncbi.nlm.nih.gov/protein/NP_003131 https://www.uniprot.org/uniprot/Q05066 https://www.wikidata.org/wiki/Q409114 A DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in humans. A transcription factor that plays an essential role in the development of the testes. It is encoded by a gene on the Y chromosome and contains a specific HMG-box domain that is found within members of the SOX family of transcription factors. SRY protein testis-determining factor