Degradation of ubiquitinated SMAD2 Authored: Orlic-Milacic, M, 2012-04-04 Edited: Jassal, B, 2012-04-10 Pubmed11158580 Pubmed22045334 Reactome Database ID Release 432176452 Reactome, http://www.reactome.org ReactomeREACT_121119 Reviewed: Huang, Tao, 2012-05-14 Ubiquitinated SMAD2 undergoes proteasome-dependent degradation. Therefore, SMURF2 decreases the level of SMAD2 in the cell, irrespective of TGF-beta signaling, and may regulate the competence of a cell to respond to TGF-beta signaling (Zhang et al. 2001). These findings are contradicted by a recent study of Smurf2 knockout mice, where Smad2 protein levels were found to be unaltered in the absence of Smurf2 (Tang et al. 2011). Ub-SMAD2