Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02 EC Number: 6.3.2.19 Edited: Jassal, B, 2006-02-14 10:42:31 Pubmed10587642 Pubmed10587654 Reactome Database ID Release 43173545 Reactome, http://www.reactome.org ReactomeREACT_6857 Reviewed: Heldin, CH, 2006-04-18 14:26:12 Reviewed: Huang, Tao, 2012-05-14 The nuclear R-SMAD:Co-SMAD complex recruits ubiquitin conjugating enzymes, such as UBE2D1 and UBE2D3, that ubiquitinate the complex and eventually lead to its proteasomal degradation. This provides an end point to the signaling pathway. p-2S-SMAD2/3:SMAD4