ITP + H2O => IMP + PPi Authored: D'Eustachio, P, 2012-10-05 Cytosolic ITPA dimer catalyzes the reaction of ITP and water to form IMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of ITP is thought to prevent its incorporation into mRNA, which would lead to aberrant protein synthesis (Lin et al. 2001; Abolhassani et al. 2010). Edited: D'Eustachio, P, 2012-10-05 ITPA hydrolyses ITP to IMP Pubmed11278832 Pubmed20081199 Reactome Database ID Release 432509827 Reactome, http://www.reactome.org ReactomeREACT_150277 Reviewed: Ito, Riyoko, 2012-10-05